出版物
约翰逊,漫画、搜索引擎优化、H.-S。,Terrell, E.M., Feffken, E.A., Lakhani, J., Song, K., Popow, O., Liu, A., Mattos, C., Morrison, D.K., Dhe-Paganon, Haigis, K., Regulation of GTPase function by autophosphorylation, Molecular Cell 82(5), 950-968 (2022).https://doi.org/10.1016/j.molcel.2022.02.011
李,Z。,马托斯C。,and Buck, M., Computational studies of the principle of dynamic-change-driven protein interactions, Structure 30(6), 909-916 (2022).https://doi.org/10.1016/j.str.2022.03.008
Cookis、t和马托斯C。,Crystal structure reveals full Ras:Raf interface and advances mechanistic understanding of Raf activation, Biomolecules, 11(7) 996 (2021).https://doi.org/10.3390/biom11070996
*封隔器,M。,*Parker, J. A., Chung, J. K., Li, Z., Lee, Y. K., Cookis, T., Guterres, H., Alvarez, S., Hossain, MDA, Donnelly, D. P., Agar, J. N., Makowski, L., Buck, M., Groves, J. T. and Mattos, C., Raf promotes dimerization of the Raf G-domain with increased allosteric connections, PNAS, 118(10) e2015648118;https://doi.org/10.1073/pnas.2015648118(2021)。(* Co-first作者)
阿加瓦尔,S。史密斯,M。,De La Rosa, I., Verba, K.A., Swartz, P., Segura-Totten, M., and Mattos, C., Development of a structure-analysis pipeline using multiple solvent crystal structures of barrier-to-autointegration factor,Acta结晶的D:结构生物学,76年,1001 - 1014 (2020)。
卡尼,b . M。,Schwabe, Marcus, K., M. Roberts, D. M., Dechene, M., Swartz, P., and Mattos, C., DRoP: Automated detection of conserved solvent binding sites on proteins,蛋白质:结构、功能和生物信息学,88年,152 - 165 (2020)。
里德·d·马托斯,C。,Targeting cancer from a structural biology perspective, in Unraveling Cancer Signaling Pathways: A Multidisciplinary Approach, Kakoli Bose and Pradip Chaudhari Editors, Springer (2019).
张成泽,H。,Banerjee, A., Marcus, K., Makowski, L., Mattos, C. Gaponenko, V. and Nussinov, R., The structural basis of the farnesylated and methylated KRas4B interaction with calmodulin,结构,27(11),1647 - 1659 (2019)。
马库斯,k和马托斯C。,Water in Ras superfamily evolution,计算化学杂志,41(5),402 - 414 (2019)。
*约翰逊,c W。、林* Y.-J。里德,D。,Parker, J., Pavlopoulos, S., Dischinger, P., Graveel, C., Aguirre, A. J., Steensma, M., Haigis, K. M., Mattos, C., Isoform-specific destabilization of the active site reveals molecular mechanism of intrinsic activation of KRas G13D,细胞的报道,28(6),1538 - 1550 (2019)。(* Co-first作者)
Wadia-Fascetti, S。马托斯C。and Cornwall, A., Advancing with the STARS: Fostering systemic inclusivity in Northeastern University’s STEM Ph.D. programs, in “Broadening STEM participation in academia: Documenting impact through empirical evidence”, Eds. Winfield, L., Wilson-Kennedy, Z., Thomas, G., and Watkins, L., ACS Books (2019).
Knihtila, R。Volmar,。,Meilleur, F. and Mattos, C., Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras,Acta Crystallogr。F,75年,111 - 115 (2019)。
Ashkar, R。,Bilheux, H., Bordallo, H., Briber, R., Callaway, D., Cheng, X., Chu, X.-Q., Curtis, J., Dadmun, M., Fenimore, P., Fushman, D., Gabel, F., Gupta, K., Herberle, F., Heinrich, F., Hong, L., Datsaras, J., Kelman, Z., Kharlampieva, E., Kneller, G. R., Kovalevskyi, A., Krueger, S., Langan, P., Libermann, R., Liu, Y., Losche, M., Lyman, E., Mao, Y., Marino, J., Mattos, C., Meilleur, F., Moody, P., Nickels, J. D., O’Dell, W., O’Neill, H., Perez-Salas, U., Peters, J., Petridis, L., Sokolov, A., Stanley, C., Wagner, N., Weinrich, M., Weiss, K., Wymore, T., Zhang, Y., and Smith, J. C., Neutron scattering in the biological sciences: progress and prospects,Acta Crystallogr。D结构生物学,74年,1129 - 1168 (2018)。
周,H。,Guterres, H., Mattos, C., Makowski, L., Predicting X-ray solution scattering from flexible macromolecules,蛋白质科学12,2023 - 2036 (2018)。
帕克,j。Volmar,。Y。,Pavlopoulos, S. and Mattos, C., K-Ras populates conformational states differently from its isoform H-Ras and oncogenic mutant K-RasG12D,结构26,810 - 820 (2018)。
帕克,j . a和马托斯C。,The K-Ras, N-Ras and H-Ras isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants,Ras在人类癌症和疾病。冷泉港地中海教谕。8(8)doi: 10.1101 / cshperspect。a031427 (2018)。
*约翰逊,c W。*里德,D。,帕克,j。索尔特,S。,Knihtila, R。,Kuzmic, P., and Mattos, C., The small GTPases K-Ras, N-Ras and H-Ras have distinct biochemical properties determined by allosteric effects,生物化学杂志》上,292年(31),12981 - 12993 (2017)。(* Co-first作者)。
* Kauke, m . J。,*Traxlmayr, M. W., *Parker, J. A., Kiefer, J. K., Knihtila, R., McGee, J., Mattos, C., and Wittrup, D. K., An engineered protein antagonist of K-Ras/B-Raf interaction,科学报告,7(1),5831 - 5839 (2017)。(* Co-first作者)
约翰逊,c W。Buhrman, G。Ting, P.Y.,Colicelli, J., and Mattos, C., Expression, Purification, Crystallization and X-ray data collection for RAS and its mutants,简单的数据,6,423 - 427 (2016)。
Knihtila, R。,Holzapfel G。维斯,K。,Meilleur, F. and Mattos, C. Neutron Crystal Structure of RAS GTPase puts in question the Protonation State of the GTP γ-Phosphate J. Mol Bio 52, 31025-36 (2015).
马托斯C。,Ras: structural details to guide direct targeting. Aging, 7(6), 344-345 (2015).
Ting, P。,Johnson, C., Mattos, C. and Colicelli, J., ABL phosphorylation of HRAS alters intrinsic hydrolysis and effector binding, FASEB (2015).
马库斯,k和马托斯C。,Direct attack on Ras: Targeting Communication Pathways and Mutation-specific Effects, Clinical Cancer Research, 21(8), 1810-1818 (2015).
帕克,j·马托斯,C。,The Ras-membrane interface: isoform-specific differences in the catalytic domain, Molecular Cancer Research, 13(4), 595-603 (2015).
Fetics美国K。,Guterres, H., Kearney, B. M., Buhrman, G. Ma, B., Nussinov, R. and Mattos, C., Allosteric effects of RasQ61L oncogenic mutation on Raf-RBD, Structure, 23(3), 505-516 (2015).
卡尼,b . M。约翰逊,C。W., Roberts, D. M., Swartz, P. and Mattos, C., DRoP: a water analysis program identifies Ras-GTP specific pathway of communication between membrane interacting regions and the active site, Journal of Molecular Biology, 426(3), 611-629 (2014).
约翰逊,C·w·马托斯,C。,The allosteric switch and conformational states in Ras-GTP affected by small molecules, in The Enzymes, Inhibitors of Ras Superfamily G-proteins, Editor Fuyu Tamanoi, Vol 33, 42-67 (2013).
马托斯C。,Johnson, M., White, H., Sears, D., Bailey, C., Bell, E., Introduction: Promoting concept driven teaching strategies in Biochemistry and Molecular Biology, Biochemistry and Molecular Biology Education, 41(5), 287-288 (2013).
Nussinov, R。,Tsai, C.-J. and Mattos, C., Pathway drug cocktail: targeting Ras signaling based on structural pathways, Trends in Molecular Medicine, 19(11), 695-704 (2013).
Holzapfel G。Buhrman, G。和马托斯C。,Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition, Biochemistry, 51, 6114-6126 (2012).
沃尔特斯,J。,Schipper, J. L., Swartz, P., Mattos, C., and Clark, A. C., Allosteric Modulation of Caspase-3 through Mutagenesis, Bioscience Reports, 32, 401-411 (2012).
盖格农,k . T。Biswas S。张,X。,Brown II, B. A., Wollenzien, P., Mattos, C. and Maxwell, E. S., The structurally conserved Nop56/58 N-terminal domain facilitates archaeal Box C/D sRNP-guided methyltransferase activity, Journal of Biological Chemistry, 287(23), 19418-19428 (2012).
之前,我一个。,Lewis, P. D., Mattos, C., A comprehensive survey of Ras mutations in cancer, Cancer Research, 72(10): 2457-2467 (2012).
马托斯和吊环D。国际晶体学表:溶剂结构,体积F,第二版,生物大分子晶体学。(Daniel m . Himmel艾迪·阿诺德,迈克尔-罗兹曼MG,阿诺德E, Eds)。威利和儿子,623 - 640 (2012)。
Buhrman G。,O’Connor, C., Zerbe, B., Kearney, B. M., Napoleon, R., Kovrigina, E. A., Vajda, S., Kozakov, D., Kovrigin, E. L., and Mattos, C., Analysis of binding site hot spots on the surface of Ras GTPase, Journal of Molecular Biology, 413, 773-789 (2011).
Biswas年代。,Buhrman G。,Gagnon, K., Mattos, C., Brown, B. and Maxwell, E., Comparative Analysis of the 15.5kD Box C/D snoRNP Core Protein in the Primitive Eukaryote Giardia lamblia Reveals Unique Structural and Functional Features, Biochemistry, 50, 2907-2918 (2011).
沃尔特斯,J。,Swartz, P., Mattos, C. and Clark, A.C., Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3, Archives of Biochemistry and Biophysics, 508, 31-38 (2011).
Burhman G。库马尔,S。Cirit, M。,Haugh, J. M., and Mattos, C. Allosteric modulation of Ras-GTP is linked to signal transduction through Raf kinase. Journal of Biological Chemistry, 286, 3323-3331 (2011).
Buhrman G。,Holzapfel G。,Fetics, S. and Mattos, C., Allosteric modulation of Ras positions Q61 for a direct role in catalysis, PNAS, 107, 4931-4936 (2010).
沃尔特斯,J。、流行、C。,Scott, F.L., Drag, M., Swartz, P., Mattos, C., Salvesen, G.S., and Clark, A.C., A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis, Biochemical Journal, 424, 335-345 (2009).
Dechene, M。眨眼,G。,Smith, M., Swartz, P. and Mattos, C., Multiple Solvent Crystal Structures of Ribonuclease A: An Assessment of the Method, Proteins: Structure, Function and Bioinformatics, 76, 861-881 (2009).
Brenke, R。,Kozakov, D., Chuang, G.-Y., Beglov, D., Hall, D., Landon, M. R., Mattos, C. and Vajda, S., Fragment-based identification of druggable “hot spots” of proteins using Fourier domain correlation techniques, Bioinformatics, 25, 621-627 (2009).
马托斯c .移除障碍之间的课堂教学和研究在实验室,ASBMB今天17 - 19 (2008)。
马托斯和克拉克,a . C。,Minimizing frustration by folding in an aqueous environment, Archives of Biochemistry and Biophysics, 469, 118-131 (2008).
Buhrman G。眨眼,G。和马托斯C。,Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf, Structure, 15, 1618-1629 (2007).
米拉姆,S.L.,好,N。I., Feeney, B., Mattos, C., Clark, A.C., Rapid Folding and Unfolding of Apaf-1 CARD, Journal of Molecular Biology, 369, 290-304 (2007).
吊环、d和马托斯C。,Location of Binding Sites on Proteins by the Multiple Solvent Crystal Structure Method, In Fragment-based Approaches in Drug Discovery, Methods and Principles in Medicinal Chemistry (Jahnke, W., Erlanson, D. A., Eds) Wiley-VCH; vol 34, 67-88 (2006).
捐助,B。、流行、C。,Swartz, P., Mattos, C. and Clark, A.C., The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)caspase-3, Biochemistry, 45, 13249-13263 (2006).
马托斯C。,Bellamacina, C., Peisach, E., Pereira, A., Vitkup, D., Petsko, G.A. and Ringe, D., Multiple Solvent Crystal Structures: Probing Binding Sites, Plasticity and Hydration, Journal of Molecular Biology, 357, 1471-1482 (2006).
Buhrman G。,Parker, B., Sohn, J., Rudolph, J. and Mattos, C., Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond, Biochemistry, 44, 5307-5316 (2005).
好,N。,Kosak, J., de Serrano, V., and Mattos, C., Crystal Structures of Ral-GppNHp and Ral-GDP Reveal Two Binding Sites That Are Also Present in Ras and Rap, Structure, 12, 2025-2036 (2004).
马托斯C。,Cohen, J.D., Green, D.F., Tidor, B., and Karplus, M., X-ray Structural and Simulation Analysis of a Protein Mutant: The Value of a Combined Approach, Proteins: Structure, Function, and Bioinformatics 55, 733-742 (2004).
Buhrman G。,de Serrano, V., and Mattos, C., Organic Solvents Order the Dynamic Switch II in Ras Crystals, Structure 11, 747-751 (2003).
马托斯C。,Protein-Water Interactions in a Dynamic World, Trends in Biochemical Sciences 27, 203-208 (2002).
马托斯和吊环D。,Proteins in Organic Solvents, Curr. Opin. Struct. Biol. 11, 761-764 (2001).
马托斯和吊环D。:溶剂结构,在国际晶体学表。(E -罗兹曼毫克,阿诺,Eds。)Kluwer学术出版社;F卷,623 - 640 (2001)
吊环、d和马托斯C。,Analysis of the Binding Surfaces of Proteins, Med. Res. Rev. 19, 321-331 (1999).
MacKerell Jr .) a D。Bashford D。Bellott, M。,Dunbrack Jr., R. L., Evanseck, J., Field, M. J., Fischer, S., Gao, J., Guo, H., Ha, S., Joseph, D., Kuchnir, L., Kuczera, K., Lau, F. T. K., Mattos, C., Michnick, S., Ngo, T., Nguyen, D. T., Prodhom, B., Reiher III, W. E., Roux, B., Schlenkrich, M., Smith, J., Stote, R., Straub, J., Watanabe, M., Wiorkiewicz-Kuczera, J., Yin, D., and Karplus, M., All-atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins, J. Phys. Chem. B 102, 3586-3616 (1998).
马托斯和吊环D。,Locating and Characterizing Binding Sites on Proteins, Nature Biotech. 14, 595-599 (1996).
艾伦,k . N。,Bellamacina, C. R., Ding, X., Jeffery, C. J., Mattos, C., Petsko, G. A., and Ringe, D., An Experimental Approach to Mapping the Binding Surfaces of Crystalline Proteins, J. Phys. Chem. 100, 2605-2611 (1996).
马托斯C。,Giammona, D., Petsko, G.A., and Ringe, D., Structural Analysis of the Active Site of Porcine Pancreatic Elastase Based on the X-Ray Crystal Structure of Complexes with Trifluoroacetyl-Dipeptide-Anilide Inhibitors, Biochemistry 34, 3193-3203 (1995).
马托斯C。,Petsko, G. A., and Karplus, M., Analysis of Two-Residue Turns in Proteins, J. Mol. Biol. 238, 733-747 (1994).
马托斯C。,Rasmussen, B., Ding, X., Petsko, G. A., and Ringe, D., Analogous Inhibitors of Elastase Do Not Always Bind Analogously, Nature Struct. Biol. 1, 55-58 (1994).
马托斯C。,and Ringe, D., Multiple Binding Modes, In 3D QSAR in Drug Design — Theory, Methods and Applications, (H. Kubinyi, ed.) ESCOM Science Publisher, Leiden (1993).